Veno-venous extracorporeal membrane oxygenation (VV-ECMO) for life-threatening isolated pulmonary anti-GBM disease

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) for life-threatening isolated pulmonary anti-GBM disease

Blog Article

Anti-glomerular basement membrane disease (anti-GBM disease) Zesters associated with renal and lung lesions has a poor prognosis.Diffuse alveolar hemorrhage (DAH) is a complication that worsens anti-GBM disease prognosis.We report a rescue case using veno-venous extracorporeal membrane oxygenation (VV-ECMO) for diffuse alveolar hemorrhage due to isolated pulmonary anti-GBM disease; a rare anti-GBM syndrome.A 30-year-old Japanese female with no past medical history.

Presented with acute hypoxemic respiratory failure requiring mechanical ventilation.Progressive deterioration and refractory hypoxemia prompted therapy with VV-ECMO.Serum anti-GBM antibody confirmed the diagnosis of anti-GBM disease.Multi-modal systemic therapy with pulse-dosed methylprednisolone, plasma exchange, and rituximab resulted in significant clinical improvement.

VV-ECMO for 10 days was uncomplicated.Renal French Fry Scoops replacement therapy was not required.The patient was extubated on day 18 and discharged from the hospital after 45 days.VV-ECMO supportive therapy for DAH with refractory respiratory failure was demonstrated to be effective pending definitive diagnostic and therapeutic management in this case of isolated pulmonary anti-GBM disease.